Nasopharyngeal carcinoma (NPC) is specifically endemic in Southern China and SE Asia. In addition to the blood tests, family history, clinical history & race are key factors in determining risk and follow up tests. Normally, positive EBV tests in high-risk populations may be followed up with ENT consultation. Examples of more definitive follow up tests are complete examination of the nasopharynx with biopsy (if indicated), CT and MRI or combination.