| 1. If an acute infection is suspected, suggest a second sample 7-14 days later and test for both IgG and IgM antibodies to look for seroconversion or a significant rise in antibody level. To aid in the diagnosis of a current infection, consider Parvovirus B19 DNA, PCR. |
| 2. In neonates with positive IgG levels must be interpreted with caution, since approximately 50% of women are immune to parvovirus B19 and the maternal IgG is transferred passively from mother to the foetus before birth. IgM assays are generally more useful indicators of infection in children below 6 months of age. |
| 3. Enzyme immunoassay tests to detect viral antibodies has several limitations. Therefore, if clinically indicated, confirmation by other methodologies or other tests are recommended. |
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| Source: Vircell. Parvovirus VirClia IgG Monotest package insert. |